Wednesday, October 8, 2025

Time Event (+)
16:00 - 16:50 Check in - Participant registration  
16:50 - 18:30 Integrative Structural Biology - Chair : Isabelle Billas, IGBMC, Illkirch (+)  
17:00 - 17:15 › The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA - Samuel Holvec, Centre for Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire  
17:15 - 17:30 › Protein kinase 1 from C. elegans obscurin reveals internal architecture of kinases - Till Dorendorf, University of Konstanz  
17:30 - 17:45 › Deciphering the mode of action and regulation of Cohesin using a simplified parasite complex - Eva Deleurence, IGBMC  
17:45 - 18:30 › 1987-2025: What a Journey ! - Dino Moras, Institut de Génétique et de Biologie Moléculaire et Cellulaire  
18:30 - 20:10 Dinner  
20:15 - 21:30 Integrative Structural Biology - Chair : Marie-Laure Diebold, IGBMC, Illkirch (+)  
20:15 - 20:30 › Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions - Edoardo Cavani, Laboratory for Biomolecular Modeling, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL)  
20:30 - 20:45 › OrfL and OrfM: Biochemical and Structural Characterization of Key Players in Horizontal Gene Transfer - Dunkan BEGUE, Cristallographie, Résonance Magnétique et Modélisations  
20:45 - 21:00 › Structural insights into MEK1-mediated ERK2 activation using an integrative approach - Jill Von Velsen, EMBL  
21:00 - 21:15 › Structural Basis for the Phospho-regulation of the RasGAP NF1 by 14-3-3 - Matthias Zeug, Biozentrum [Basel, Suisse]  
21:15 - 21:30 › Crystallography is a powerful tool for scientific communication - Claude Sauter, Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 67084 Strasbourg  
21:30 - 23:55 Happy Hour  

Thursday, October 9, 2025

Time Event (+)
09:00 - 10:45 Structural Proteomics and Interactomics - Chair : Elodie Monsellier, IGBMC, Illkirch (+)  
09:00 - 09:45 › Beyond Crystals & Cryo‑EM: How Mass Spectrometry Is Rewriting Structural Biology - Sarah Cianferani, Laboratoire de Spectrométrie de Masse Bio-Organique (LSMBO), IPHC, UMR 7178, Université de Strasbourg, CNRS, 25 rue Becquerel, 67087, Strasbourg, France  
09:45 - 10:00 › Combination of native mass spectrometry, ion mobility, and collision induced unfolding experiments in the chromatographic time scale to unravel the structure of hemoglobin bird species - Turkan Nabiyeva, BioOrganic Mass Spectrometry Laboratory (LSMBO) - Léa Letissier, BioOrganic Mass Spectrometry Laboratory (LSMBO) - Maily Kervella, Ecology, Physiology and Ethology Department (DEPE) - Stephane Hourdez, Laboratoire dÉcogéochimie des environnements benthiques - Christine Schaeffer, BioOrganic Mass Spectrometry Laboratory (LSMBO) - François Criscuolo, Ecology, Physiology and Ethology Department (DEPE) - Fabrice Bertile, BioOrganic Mass Spectrometry Laboratory (LSMBO) - Sarah Cianferani, BioOrganic Mass Spectrometry Laboratory (LSMBO) - Oscar Hernandez-Alba, BioOrganic Mass Spectrometry Laboratory (LSMBO)  
10:00 - 10:15 › Accelerate Structural Studies with Novel Insights from Mass Photometry - Tobias Gubbey, Refeyn  
10:15 - 10:30 › Proximity-dependent labelling to identify mechanosensory signalling cascades - Isabel Martin, Universität Konstanz  
10:30 - 10:45 › High-throughput quantitative interactomics establish the biochemical basis for protein complex assembly on a system-wide scale - Kristof Görlitz, IGBMC Illkirch  
10:45 - 11:15 Coffee break  
11:15 - 13:00 Latest developments in Cryo-EM and Crystallography - Chair : Gabor Papai, IGBMC, Illkirch (+)  
11:15 - 12:00 › Exploring the Molecular Architecture of Native Actin Assemblies using Cryo-electron Tomography - Marion JASNIN, Helmholtz Zentrum München  
12:00 - 12:15 › Empowering Science Through Integrated Core Facility Support: The Role of PTPSP at EPFL - Anna-Sophia Krebs, EPFL - Jonathan Schneider, EPFL  
12:15 - 12:30 › Streptavidin affinity grids as sample supports for cryo-electron microscopy - Nils Marechal, IGBMC  
12:30 - 12:45 › Deciphering CRISPR-Cas Activity and Chromatin Interactions for Enhanced Gene Editing Precision - Babatunde Ekundayo, Laboratory of Biological Electron Microscopy, EPFL  
12:45 - 13:00 › Introducing Krios 5 Cryo-TEM- Enhanced throughput for SPA and a contamination free workflow for Cryo-ET - Dhirendra Singh, Thermo Fisher Scientific  
13:00 - 14:30 Lunch  
14:30 - 16:00 Hike of free time  
16:00 - 17:30 Alsacian Vine and Kouglof tasting with vinemaker Domaine Fritz-Schmitt from Ottrott  
17:30 - 19:00 Integrative Structural Biology - Chair : Valérie Lamour, IGBMC, Illkirch (+)  
17:30 - 18:15 › How Ribosomes are Made in Human Cells - Arnaud Vanden Broeck, University of Liege  
18:15 - 18:30 › Insights into the assembly of mitochondrial respiratory complex III - Jorge Jimenez-Niebla, University of Freiburg, Spemann Graduate School of Biology and Medicine  
18:30 - 18:45 › Towards structural understanding of UBE3A mediated p53 degradation - Nandita Bodra, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France  
18:45 - 19:00 › Structural insights into TRPM4 regulation by phosphatidylinositol 4,5-bisphosphate (PIP₂)​ - Dominic Schneiter, Institute of Biochemistry and Molecular Medicine, University of Bern  
19:00 - 20:30 Dinner  
20:30 - 21:30 Latest developments in Cryo-EM and Crystallography - Chair : Nils Maréchal, IGBMC, Illkirch (+)  
20:30 - 20:45 › Practical NMR at EPFL's Protein Production and Structure Core Facility - Luciano Abriata, Ecole Polytechnique Fédérale de Lausanne  
20:45 - 21:00 › Structure of The Human Native Saga Complex Through a Tag-Less Purification Method - Mylene DAMILOT, SCHULTZ team  
21:00 - 21:15 › Overview of Macromolecular Crystallography at SLS 2.0 and SwissFEL - Guillaume Gotthard, Paul Scherrer Institute  
21:15 - 21:30 › Dynamics of our Light-Receptor for Vision, Rhodopsin, Using an X-Ray Free Electron Laser - PANNEELS Valerie, Paul Scherrer Institut  
21:30 - 23:55 Happy Hour  

Friday, October 10, 2025

Time Event (+)
09:00 - 10:30 Integrative Structural Biology - Chair : Christophe Romier, IGBMC, Illkirch (+)  
09:00 - 09:45 › From Biophysics to Medicinal Chemistry: Combining Technologies to Support Drug Discovery - Denis Zeyer, NovAliX  
09:45 - 10:00 › ZHNIT6, a major RUVBL1/2 ATPases cofactor of box C/D snoRNP biogenesis - Benoît BRAGANTINI, Ingénierie Moléculaire, Cellulaire et Physiopathologie, Biophysique et Biologie Structurale (B2S) - Service Mutualisé de Plateformes (SMP)  
10:00 - 10:15 › Structural and functional study of an unconventional dsRNA binding protein (dsRBP) - Romain VINCENT, Architecture et Réactivité de l'ARN  
10:15 - 10:30 › Structural Characterization of Pore-Forming Toxins in Membrane-Like Environments - Jana Anton, Ecole Polytechnique Fédérale de Lausanne  
10:30 - 11:00 Coffee break  
11:00 - 12:15 Computational Structural Biology - Chair : Christian Jelsch, CRM2, Nancy (+)  
11:00 - 11:15 › Toward Accurate van der Waals Modeling: A Comparative Study of Empirical and Physical Approaches Using MoProSuite - Haritha Mambatta  
11:15 - 11:30 › Context-aware geometric deep learning for protein sequence design - Mariajose Marcaida, Laboratory for Biomolecular Modeling, EPFL  
11:30 - 11:45 › Allosteric Pocket Prediction Using Protein Language Models - Victor Pryakhin, Laboratoire Lorrain de Recherche en Informatique et ses Applications  
11:45 - 12:00 › Principles of Mg2+ binding to RNA inferred from an analysis of a bacterial ribosome at 1.55 Å resolution - Pascal Auffinger, Architecture et Réactivité de lÁRN  
12:00 - 12:15 › Describing conformations and transitions in single particle cryo EM data of proteins by use of density deformation tools and the Boltzmann distribution - Mette Ahrensback Roesgaard, Biozentrum, University of Basel  
12:15 - 14:00 Lunch  
14:30 - 14:30 Check out  
  
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